Have 7 or more max red hearts at one time
Hold 55 or more pennies at one time
Beat 2 levels in a row without picking up any hearts
Beat 2 levels in a row without taking damage
Make 3 deals with the devil in one run
Have 4 or more soul hearts at one time
Beat the Womb for the first time
Beat the Basement 40 times
Beat the Basement/Cellar without taking damage
Beat the Caves/Catacombs without taking damage
Beat the Depths/Necropolis without taking damage
Beat the Womb/Utero without taking damage
Beat the Chest or Dark Room without taking damage
Beat the Dark Room with Isaac
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball
Kill Mom's Heart 10 times
Kill Mom's Heart 11 times
Collect all items and unlock all secrets and endings
Finish the game's final secret
Beat Greed Mode with Azazel
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Kill Delirium with Apollyon
Beat Greedier Mode with Apollyon
Complete all hard mode marks with Apollyon
Kill Delirium for the first time
