Get a combo-pop of 100 or more germs with one shot
Pop a germ of size 25x or greater
Finish any Puzzle level with a single shot
Complete 20 different levels in a single run in Puzzle Mode
Complete all Story Mode levels
Complete all Puzzle Mode levels
Win the 15th round in a Duel match against The Germinator
Fire 50 germs in a single Story, Duel, or Arcade level
Complete a Story Mode level in under 30 seconds
Lose any Story Mode level within 5 seconds
Collect all stars in Puzzle and Story Mode