Complete Chapter 1: "Worlds Apart"
Complete Chapter 2: "Another Day at the Office"
Complete Chapter 3: "Return to the Megavents"
Complete Chapter 4: "Rendezvous with Fate"
Complete Chapter 5: "Emergency Care"
Complete Chapter 6: "Nowhere to Hide"
Complete Chapter 7: "Life and Death"
Complete Chapter 8: "In the Hearts of Men"
Complete Chapter 9: "Escaping the Ishimura"
Complete Chapter 10: "Secrets and Salvation"
Complete the game on "Normal"
Complete the game on "Hard"
Complete the game on "Expert"
Complete the game on "Impossible"
Beat the top score on the "Extraction Site" Challenge
Beat the top score on the "Central Plaza" Challenge
Beat the top score on the "Maintenance Bay" Challenge
Beat the top score on the "Mess Hall" Challenge
Beat the top score on the "Medical Bay" Challenge
Beat the top score on the "Water Tunnels" Challenge
Beat the top score on the "East Grow Chamber" Challenge
Beat the top score on the "Shuttle Bay 47" Challenge
Beat the top score on the "Atrium" Challenge
Beat the top score on the "Life Support Room" Challenge
Survive the shuttle flight with less than 10% shields intact
Play cooperatively with a second player
Shoot the box hanging from the crane on the surface of Aegis 7
Open the secret weapons store in P-Sec
Take a minor detour in the megavents
Admire the view in the crashed shuttle
Defeat the giant necromorph in the water tunnels
Defeat the giant necromorph on the hull of the Ishimura
Complete any level with at least 80% Perfect Reloads
Complete any level with at least 80% Weapon Accuracy
Complete any level with a 5 star rating
Earn 10 stars on one profile
Earn 30 stars on one profile
Earn 50 stars on one profile
Collect all weapons, text logs and audio logs on Chapter 1: "Worlds Apart"
Collect all weapons, text logs and audio logs on Chapter 3: "Return to the Megavents"
Collect all weapons, text logs and audio logs on Chapter 5: "Emergency Care"
Collect all weapons, text logs and audio logs on Chapter 8: "In The Hearts of Men"
Collect all weapons, text logs and audio logs on Chapter 9: "Escaping the Ishimura"
Collect every weapon on one profile
Max out all upgrades for every weapon on one profile
